Previously, we highlighted the risks associated with obtaining compounded GLP-1 and semaglutide prescriptions online. Addressing this growing concern is even more critical now. While these products are often marketed as cheaper alternatives, compounded and non-FDA-approved semaglutide carries significant health risks.

Understanding the Issue

Compounding involves modifying or combining ingredients to create customized medications. This means that some pharmacies are using the process to replicate FDA-approved medications like Ozempic or Wegovy without adhering to regulatory standards, allowing them to create a product that can be sold for significantly cheaper and one that isn’t as highly regulated. 

Misleading Marketing Tactics

Companies often market compounded GLP-1 medications with terms like “customized,” “bioidentical,” “FDA-regulated facility,” or “personalized,” suggesting they are as effective and safe as FDA-approved drugs. However, these products frequently contain the salt form of semaglutide, which is not FDA-approved and has not undergone rigorous testing for safety or efficacy.

Certain online telehealth platforms and in-person clinics offer these compounds with minimal medical oversight, sometimes prescribing them after superficial evaluations or bypassing consultations entirely.

Risks of Compounded and Non-FDA-Approved Medications

Using compounded semaglutide exposes patients to serious risks, including:

  • Incorrect Dosing: Variability in strength can result in overdoses or underdoses.
  • Contaminants or Impurities: Without FDA oversight, these medications may contain harmful substances.
  • Adverse Events: Severe side effects, including vomiting, dehydration, and hospitalization, have been reported.

In 2024, the FDA received over 600 adverse event reports related to compounded semaglutide and tirzepatide, prompting a public warning. Muscle mass loss has also been observed as a potential side effect when GLP-1 medications are misused, jeopardizing overall health.

Real-World Consequences

Just because some people are using these compounded GLP-1 medications without seeing dangerous side effects (yet) doesn’t mean they’re worth the risk. Incorrect dosing instructions led to severe side effects, including vomiting blood. Tragically, the U.S. has already seen 10 deaths and over 100 hospitalizations linked to off-brand Ozempic.

Why FDA Approval Matters

FDA-approved medications like Ozempic and Wegovy undergo extensive clinical trials to ensure safety, efficacy, and consistent quality. These medications are prescribed under strict medical supervision, with proper guidance on dosing and monitoring for side effects.

If a deal on GLP-1 medications seems too good to be true, it almost certainly is. The price of FDA-approved medications reflects the research and safety protocols behind them. Be cautious of products claiming to offer the same benefits at a fraction of the cost.

Stay Safe with GLP-1 Medications

If you’re considering GLP-1 medications, prioritize your safety:

  • Consult a Trusted Healthcare Provider: Avoid sources promising quick results with minimal lifestyle modifications or low monthly subscription prices.
  • Verify Your Prescription: Ensure your medication is FDA-approved and dispensed by a licensed pharmacy.
  • Be Wary of Buzzwords: Terms like “the same active ingredient” or “bioidentical” often indicate compounded products.

Your health is too important to risk on unverified medications. Whether or not a GLP-1 medication is part of your journey, it doesn’t define your ability to achieve your weight loss goals. At Alaska Premier Health, we’re committed to helping you reach those goals safely and effectively. If a GLP-1 medication is something you’d like to try, we’ll ensure it’s prescribed correctly and in addition to the rest of your metabolic health program, not as a quick-fix solution. Your health and success are our top priorities.